(+)-FANGCHINOLINE
- Product Name
- (+)-FANGCHINOLINE
- CAS No.
- 436-77-1
- Chemical Name
- (+)-FANGCHINOLINE
- Synonyms
- Hanfangchin B（Fangchinoline）;(+)-limacine;Tetrandrine B;FANGCHINO-LINE;Hanfangichin B;(+)-FANGCHINOLINE;FANGCHINOLINE (RG);7-o-demethyltetrandrine;12-O-MethylatherosperMoline;(+)-FANGCHINOLINE USP/EP/BP
- CBNumber
- CB6221346
- Molecular Formula
- C37H40N2O6
- Formula Weight
- 608.72
- MOL File
- 436-77-1.mol
(+)-FANGCHINOLINE Property
- Melting point:
- 240～242℃
- Boiling point:
- 709.7±60.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- Soluble in chloroform and methanol;
- pka
- 9.38±0.20(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
- Water Solubility
- slightly soluble in water
Safety
- HS Code
- 2939.79.0000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F1173
- Product name
- Fangchinoline
- Packaging
- 20MG
- Price
- $75
- Updated
- 2024/03/01
- Product number
- F1173
- Product name
- Fangchinoline
- Packaging
- 100MG
- Price
- $226
- Updated
- 2024/03/01
- Product number
- 29243
- Product name
- Fangchinoline
- Packaging
- 5mg
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 29243
- Product name
- Fangchinoline
- Packaging
- 10mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 29243
- Product name
- Fangchinoline
- Packaging
- 50mg
- Price
- $315
- Updated
- 2024/03/01
(+)-FANGCHINOLINE Chemical Properties,Usage,Production
Description
A bisbenzylisoquino!ine alkaloid obtained from Limacia cuspidata (Miers.) Hook. f. et Thorn., the base crystallizes from Me2CO in the form of long, colourless needles. It is strongly laevorotatory with [α]D - 2120 (CHCI3) and has been shown to be the optical antipode of fanchinoline (q.v.).
Description
Fangchinoline is an alkaloid that has been found in S. tetrandrae and has diverse biological activities, including anti-inflammatory, neuroprotective, and anticancer properties. It inhibits the activity of sheep COX and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells with IC50 values of 129 and 3.7 μM, respectively. Fangchinoline (1 and 10 μM) reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons. It decreases proliferation of PC3 human prostate cancer cells by 63 and 86% when used at concentrations of 20 and 30 μM, respectively. Fangchinoline reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 5 mg/kg per day for 12 days.
Uses
(+)-Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.
Definition
ChEBI: A bisbenzylisoquinoline alkaloid that is (1beta)- berbaman which has been substituted by methyl groups at the 2 and 2' positions, by methoxy groups at the 6, 6', and 12 positions, and by a hydroxy group at position 7. Isolated from S ephania tetrandra, it has been found to possess neuroprotective and anti-tumour activity.
References
Tomita, Furukawa., Tetrahedron Lett., 4293 (1966)
(+)-FANGCHINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-FANGCHINOLINE Suppliers
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View Lastest Price from (+)-FANGCHINOLINE manufacturers
- Product
- (+)-FANGCHINOLINE 436-77-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-16
- Product
- (+)-FANGCHINOLINE 436-77-1
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2023-03-29
- Product
- Fangchinoline 436-77-1
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-10-09